abstract：:Glioblastoma, the most lethal form of brain cancer, is characterized by fast growth, migration and invasion of the surrounding parenchyma, with epithelial-to-mesenchymal transition (EMT)-like process being mostly responsible for tumour spreading and dissemination. A number of actors, including cadherins, vimentin, tra...

journal_title：Cellular signalling

authors： Cutone A,Colella B,Pagliaro A,Rosa L,Lepanto MS,Bonaccorsi di Patti MC,Valenti P,Di Bartolomeo S,Musci G

更新日期：2020-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive impairments. The classical symptoms of the disease include gradual deterioration of memory and language. Epidemiological studies indicate that around 25-40% of AD patients have sleep-wake cycle disturbances. Importantly, a series of st...

journal_title：Cellular signalling

authors： Havekes R,Heckman PRA,Wams EJ,Stasiukonyte N,Meerlo P,Eisel ULM

更新日期：2019-12-01 00:00:00

abstract：:Induction of nitrosative stress has been observed in various cancer types and in tumor environment. However, it is still unclear how cancer cells combat the effect of nitrosative stress. The main targets of nitrosative stress in cells are cellular lipids, proteins and DNA. Autophagy or self-cleaning generates energy f...

journal_title：Cellular signalling

authors： Chakraborty S,Datta S,Ghosh S

更新日期：2019-12-01 00:00:00

abstract：:β-Arrestins are multifunctional adaptor proteins best know for their vital role in regulating G protein coupled receptor (GPCR) trafficking and signaling. β-arrestin2 recruitment and receptor internalization of corticotropin-releasing factor receptor 1 (CRFR1), a GPCR whose antagonists have been shown to demonstrate b...

journal_title：Cellular signalling

authors： Gupta S,Abd-Elrahman KS,Albaker A,Dunn HA,Ferguson SSG

更新日期：2019-11-01 00:00:00

abstract：:Recent reports show that protein kinase A (PKA), but not exchange protein activated by cAMP (EPAC), acts in a cell autonomous manner to constitutively reduce the angiogenic sprouting capacity of murine and human endothelial cells. Specificity in the cellular actions of individual cAMP-effectors can be achieved when a ...

journal_title：Cellular signalling

authors： MacKeil JL,Brzezinska P,Burke-Kleinman J,Theilmann AL,Nicol CJB,Ormiston ML,Maurice DH

更新日期：2019-10-01 00:00:00

abstract：:Integrin β6 (ITGB6), an epithelial-specific integrin, is upregulated in oral squamous cell carcinomas (OSCC) and is associated with progression and metastasis of OSCC. Lysophosphatidic acid (LPA), an important bioactive phospholipid present in saliva, has also been related to OSCC cell migration and invasiveness. LPA ...

journal_title：Cellular signalling

authors： Xu M,Yin H,Cai Y,Huang W,Ji Q,Liu F,Shi S,Deng X

更新日期：2019-08-01 00:00:00

abstract：:Transmembrane prostate androgen-induced protein (TMEPAI) is a type I transmembrane protein induced by several intracellular signaling pathways such as androgen, TGF-β, EGF, and Wnt signaling. It has been reported that TMEPAI functions to suppress TGF-β and androgen signaling but here, we report a novel function of TME...

journal_title：Cellular signalling

authors： Amalia R,Abdelaziz M,Puteri MU,Hwang J,Anwar F,Watanabe Y,Kato M

更新日期：2019-07-01 00:00:00

abstract：:Nur77 (NR4A1) plays an important role in various inflammatory responses. Nur77 is rapidly degraded in cells and its protein level is critically controlled. Although few E3 ligases regulating the Nur77 protein have been defined, the deubiquitinase (DUB) responsible for Nur77 stability has not been reported to date. We ...

journal_title：Cellular signalling

authors： Pei HZ,Huang B,Chang HW,Baek SH

更新日期：2019-07-01 00:00:00

abstract：:Clinical studies have elucidated the negative correlation between microtubules-associated protein 1 light chain 3-B (LC3B) protein expression and overall survival of breast cancer patients. Our previous data demonstrated corticortropin-releasing hormone family (CRHs) suppressed migration of breast cancer cells via CRH...

journal_title：Cellular signalling

authors： Jin L,Qian Y,Zhou J,Dai L,Cao C,Zhu C,Li S

更新日期：2019-06-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP), a master switch of allergic inflammation, plays an important role in the pathogenesis of allergic diseases. Although many compounds upregulate TSLP expression in vivo or in vitro, most of them are pollutants or toxicants. In the previous study, for the first time, we found that a s...

journal_title：Cellular signalling

authors： Weng Y,Wang J,Yang Z,Xi M,Duan J,Guo C,Yin Y,Segawa R,Moriya T,Yonezawa T,Cha BY,Woo JT,Wen A,Hirasawa N

更新日期：2019-05-01 00:00:00

abstract：:Persistent exposure to ambient fine particulate matter (PM2.5) can exacerbate allergic diseases in humans. Mast cells play an important role in allergic inflammation in peripheral tissues, such as skin, mucosa, and lung. Engagement of the high-affinity Fc receptor leads to mast cell degranulation, releasing a variety ...

journal_title：Cellular signalling

authors： Jin Y,Zhu M,Guo Y,Foreman D,Feng F,Duan G,Wu W,Zhang W

更新日期：2019-05-01 00:00:00

abstract：:Pseudoxanthoma elasticum is an autosomal recessive genodermatosis with variable expression, due to mutations in the ABCC6 or ENPP1 gene. It is characterized by elastic fiber mineralization and fragmentation, resulting in skin, eye and cardiovascular symptoms. Significant advances have been made in the last 20 years wi...

journal_title：Cellular signalling

authors： Van Gils M,Nollet L,Verly E,Deianova N,Vanakker OM

更新日期：2019-03-01 00:00:00

abstract：:The global prevalence of chronic renal failure (CRF) has significantly elevated with various reports indicating there to be a 10% worldwide rate. The functions of long non-coding RNAs (lncRNAs) and their deeper association with CRF at present remain poorly understood. Hence, the aim of the present study was to investi...

journal_title：Cellular signalling

authors： Chen W,Zhou ZQ,Ren YQ,Zhang L,Sun LN,Man YL,Wang ZK

更新日期：2019-02-01 00:00:00

abstract：:Photodamage in chronically sun-exposed skin manifests clinically as deep wrinkles and histologically as extensive remodelling of the dermal extracellular matrix (ECM) and in particular, the elastic fibre system. We have shown previously that loss of fibrillin microfibrils, a key elastic fibre component, is a hallmark ...

journal_title：Cellular signalling

authors： Hibbert SA,Watson REB,Griffiths CEM,Gibbs NK,Sherratt MJ

更新日期：2019-02-01 00:00:00

abstract：:Glucuronyl C5-epimerase (Hsepi) catalyzes the conversion of glucuronic acid to iduronic acid in the process of heparan sulfate biosynthesis. Targeted interruption of the gene, Glce, in mice resulted in neonatal lethality with varied defects in organ development. To understand the underlying molecular mechanisms of the...

journal_title：Cellular signalling

authors： Batool T,Fang J,Jansson V,Zhao H,Gallant C,Moustakas A,Li JP

更新日期：2019-02-01 00:00:00

abstract：:Human Glioblastoma is one deadly disease; the median survival time is reported to be 13.9 months after treatment. In the present study, we discovered that DHX33 is highly expressed in 84% of all Glioblastoma multiforme (GBM). Knockdown of DHX33 led to significant reduced proliferation and migration in glioblastoma cel...

journal_title：Cellular signalling

authors： Wang H,Yu J,Wang X,Zhang Y

更新日期：2019-02-01 00:00:00

abstract：:Macropinocytosis is an actin-dependent endocytic mechanism mediating internalization of extracellular fluid and associated solutes into cells. The present study was designed to identify the specific protein kinase C (PKC) isoform(s) and downstream effectors regulating actin dynamics during macropinocytosis. We utilize...

journal_title：Cellular signalling

authors： Singla B,Lin HP,Ghoshal P,Cherian-Shaw M,Csányi G

更新日期：2019-01-01 00:00:00

abstract：:The kidney is one of the fastest-aging organs, and renal senescence has become a major disease affecting human health. Renal cellular senescence is regulated by the joint action of multiple signal transduction pathways. The previous study by our research group found that the Janus kinase 2 (JAK2)/signal transducer and...

journal_title：Cellular signalling

authors： Yang S,Sun D,Wang L,Wang X,Shi M,Jiang X,Gao X

更新日期：2019-01-01 00:00:00

abstract：:SIRT1 is a highly conserved type III acetyltransferase gene located on chromosome 10 in mammals that belong to the Sirtuins family. In order to explore the effects of the SIRT1 gene in the ATDC5 cell line, an RNAi SIRT1 target sequence was designed and synthesized, aimed to knockdown the expression of SIRT1 in ATDC5 b...

journal_title：Cellular signalling

authors： Yu F,Yuan Y,Li D,Kou Y,Jiang B,Zhang P

更新日期：2019-01-01 00:00:00

abstract：:Both sphingosine-1-phosphate receptor-2 (S1PR2) and cytosolic phospholipase A2 (cPLA2) are implicated in the disruption of cerebrovascular integrity in experimental stroke. However, the role of S1PR2 in induction of cPLA2 phosphorylation during cerebral ischemia-induced endothelial dysfunction remains unknown. This st...

journal_title：Cellular signalling

authors： Cao C,Dai L,Mu J,Wang X,Hong Y,Zhu C,Jin L,Li S

更新日期：2019-01-01 00:00:00

abstract：:Protectin DX (PDX), which is a novel regulator of 5' adenosine monophosphate-activated protein kinase (AMPK), has recently gained attention for its ability to improve several metabolic diseases. However, the function of PDX in vascular endothelial cells remains unclear. To confirm the protective effects of PDX on endo...

journal_title：Cellular signalling

authors： Hwang HJ,Jung TW,Kim JW,Kim JA,Lee YB,Hong SH,Roh E,Choi KM,Baik SH,Yoo HJ

更新日期：2019-01-01 00:00:00

abstract：:Calcium/calmodulin dependent protein kinase IIδ (CaMKIIδ) acts as a molecular switch regulating cardiovascular Ca2+ handling and contractility in health and disease. Activation of CaMKIIδ is also known to regulate cardiovascular inflammation and is reported to be required for pro-inflammatory NF-κB signalling. In this...

journal_title：Cellular signalling

authors： Martin TP,McCluskey C,Cunningham MR,Beattie J,Paul A,Currie S

更新日期：2018-11-01 00:00:00

abstract：:Obesity is a widespread health problem that brings about various adipose tissue dysfunctions. The balance of energy storage and energy expenditure is critical for normal fat accumulation and lipid metabolism. Therefore, understanding the molecular basis of adipogenesis and thermogenesis is essential to maintain adipos...

journal_title：Cellular signalling

authors： Chen C,Cui Q,Zhang X,Luo X,Liu Y,Zuo J,Peng Y

更新日期：2018-11-01 00:00:00

abstract：:Endothelial cell apoptosis induced by hypoxia is implicated in the pathogenesis of vascular diseases. However, the underlying mechanism is not clearly elucidated. In this study, we found that hypoxia increased Mxi1-0 expression, and the Mxi1-0 siRNA could inhibit caspase-8 activation and apoptosis in HUVECs induced by...

journal_title：Cellular signalling

authors： Hu Z,Wang F,Wu Z,Gu H,Dong N,Jiang X,Xu J,Wu Z,Wechsler DS,Zheng D

更新日期：2018-11-01 00:00:00

abstract：:A pathological hallmark of Alzheimer's disease (AD) is the aggregation of amyloid-β peptides (Aβ) into fibrils, leading to deposits in cerebral parenchyma and vessels known as cerebral amyloid angiopathy (CAA). Platelets are major players of hemostasis but are also implicated in AD. Recently we provided strong evidenc...

journal_title：Cellular signalling

authors： Donner L,Gremer L,Ziehm T,Gertzen CGW,Gohlke H,Willbold D,Elvers M

更新日期：2018-10-01 00:00:00

abstract：:A critical aspect of understanding the regulation of signal transduction is not only to identify the protein-protein interactions that govern assembly of signaling pathways, but also to understand how those pathways are regulated in time and space. In this report, we have applied both gain-of-function and loss-of-func...

journal_title：Cellular signalling

authors： Zhang J,Wang Z,Zhang S,Chen Y,Xiong X,Li X,Tonks NK,Fan G

更新日期：2018-10-01 00:00:00

abstract：:Endothelial cell activation by proinflammatory stimuli drives leukocyte recruitment through enhanced expression of counter-receptors such as vascular cell adhesion molecule-1 (VCAM-1). We previously demonstrated that activation of the receptor tyrosine kinase EphA2 with its ligand ephrin-A1 induces VCAM-1 expression. ...

journal_title：Cellular signalling

authors： Funk SD,Finney AC,Yurdagul A Jr,Pattillo CB,Orr AW

更新日期：2018-09-01 00:00:00

abstract：:Dengue virus (DENV) infection is a disease that is endemic to many parts of the world, and its increasing prevalence ranks it among the diseases considered to be a significant threat to public health. The clinical manifestations of DENV infection range from mild dengue fever (DF) to more severe dengue hemorrhagic feve...

journal_title：Cellular signalling

authors： Sreekanth GP,Yenchitsomanus PT,Limjindaporn T

更新日期：2018-08-01 00:00:00

abstract：:Insulin/IGF-1 action is driven by a complex and highly integrated signalling network. Loss-of-function studies indicate that the major insulin/IGF-1 receptor substrate (IRS) proteins, IRS-1 and IRS-2, mediate different biological functions in vitro and in vivo, suggesting specific signalling properties despite their h...

journal_title：Cellular signalling

authors： Rabiee A,Krüger M,Ardenkjær-Larsen J,Kahn CR,Emanuelli B

更新日期：2018-07-01 00:00:00

abstract：:Metastasis is the leading cause of mortality in patients with highly invasive cancers and, as such, is a major problem for medicine. It has been increasingly recognized that cancer-related inflammation plays an important role in promoting invasion and the metastatic process in which cell motility and upregulation of p...

journal_title：Cellular signalling

authors： Zaremba-Czogalla M,Hryniewicz-Jankowska A,Tabola R,Nienartowicz M,Stach K,Wierzbicki J,Cirocchi R,Ziolkowski P,Tabaczar S,Augoff K

更新日期：2018-07-01 00:00:00

abstract：:Cancer cells are able to survive under conditions that cause endoplasmic reticulum stress (ER-stress), and can adapt to this stress by upregulating cell-survival signalling pathways and down-regulating apoptotic pathways. The cellular response to ER-stress is controlled by the unfolded protein response (UPR). Small Rh...

journal_title：Cellular signalling

authors： Bright MD,Clarke PA,Workman P,Davies FE

更新日期：2018-04-01 00:00:00

abstract：:The HMG-box protein 1 (HBP1) is a transcriptional regulator and a potential tumor suppressor that controls cell proliferation, differentiation and oncogene-mediated senescence. In a previous study, we showed that AKT activation through the PI3K/AKT/FOXO pathway represses HBP1 expression at the transcriptional level in...

journal_title：Cellular signalling

authors： Bollaert E,Johanns M,Herinckx G,de Rocca Serra A,Vandewalle VA,Havelange V,Rider MH,Vertommen D,Demoulin JB

更新日期：2018-04-01 00:00:00

abstract：:Inflammation is characterized by early influx of polymorphonuclear neutrophils (PMNs), followed by a second wave of monocyte recruitment. PMNs mediate monocyte recruitment via their release of heparin binding protein (HBP), which activates CCR2 (CC-chemokine receptor 2) on monocytes. However, the pathways for such sig...

journal_title：Cellular signalling

authors： Chang M,Guo F,Zhou Z,Huang X,Yi L,Dou Y,Huan J

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Bronchial fibroblasts are the main structural cells responsible for extracellular matrix production and turnover in lung tissue. They play a key role in airway remodelling in asthma through different cytokines including interleukin (IL-6). OBJECTIVE:To decipher IL-6 signalling in bronchial fibroblasts obtai...

journal_title：Cellular signalling

authors： Salem IH,Plante S,Gounni AS,Rouabhia M,Chakir J

更新日期：2018-03-01 00:00:00

abstract：:Deficits in brain function that are associated with aging and age-related diseases benefit very little from currently available therapies, suggesting a better understanding of the underlying molecular mechanisms is needed to develop improved drugs. Here, we review the literature to test the hypothesis that a break dow...

journal_title：Cellular signalling

authors： Kelly MP

更新日期：2018-01-01 00:00:00

abstract：:Tamoxifen resistance represents a daunting challenge to the successful treatment for breast cancer. Krüppel-like factor 4 has critical roles in the development and progression of breast cancer, but its expression, function and regulation in the efficacy of TAM therapy in breast cancer have yet to be investigated. Here...

journal_title：Cellular signalling

authors： Jia Y,Zhou J,Luo X,Chen M,Chen Y,Wang J,Xiong H,Ying X,Hu W,Zhao W,Deng W,Wang L

更新日期：2018-01-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs) constitute the largest and most diverse protein family in the human genome with over 800 members identified to date. They play critical roles in numerous cellular and physiological processes, including cell proliferation, differentiation, neurotransmission, development and apoptosis...

journal_title：Cellular signalling

authors： Nieto Gutierrez A,McDonald PH

更新日期：2018-01-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is characterized by genomic and epigenomic alterations. However, the mechanisms underlying oral squamous cell carcinoma tumorigenesis and progression remain to be elucidated. Long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and extracellular RNAs (exRNAs) are emerging group...

journal_title：Cellular signalling

authors： Momen-Heravi F,Bala S

更新日期：2018-01-01 00:00:00

abstract：:Jumonji (Jmj)/Jarid2 is a DNA-binding transcriptional repressor mediated via histone methylation. Nevertheless, the well-known function of Jmj is as a scaffold for the recruitment of various complexes including Polycomb repressive complex 2 (PRC2), and required for mouse embryonic stem cell development. However, PRC2 ...

journal_title：Cellular signalling

authors： Suong DNA,Shimaji K,Pyo JH,Park JS,Yoshida H,Yoo MA,Yamaguchi M

更新日期：2018-01-01 00:00:00

abstract：:Metformin, the most used drug for the treatment of diabetes type 2 patients, has been shown to have anti-cancer properties. In this study, we found that metformin induced apoptosis in Primary Effusion Lymphoma (PEL) cells, an aggressive B cell lymphoma associated with KSHV against which the conventional therapies usua...

journal_title：Cellular signalling

authors： Granato M,Gilardini Montani MS,Romeo MA,Santarelli R,Gonnella R,D'Orazi G,Faggioni A,Cirone M

更新日期：2017-12-01 00:00:00